A Drug for All Seasons
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چکیده
Fluoroquinolones have become one of the mainstays of antibacterial therapy, regarded as a major antimicrobial class, with efficacy against a wide range of important pathogens. And among the fluoroquinolones, levofloxacin continues to stand out as one, if not the, most important fluoroquinolone. While the history of these agents first started in 1962 with the development of nalidixic acid, it was not until the late 1970s that the first fluoroquinolone, norfloxacin, was produced. Ofloxacin, a racemic compound composed of two stereo isomers, was then introduced to the market in 1985, rapidly carving out a role for itself, particularly in the treatment of urinary tract disease and lower respiratory tract infections. The excellent oral absorption of ofloxacin with its broad spectrum of activity provided clinicians with an effective antibacterial that could safely be prescribed on an outpatient basis. When first introduced fluoroquinolones were primarily recommended for Gram-negative bacilli, especially those causing urinary tract infections. They were also recommended for enteric infections, selective decontamination in patients with neutropenia, sexually transmitted diseases including Chlamydia spp., skin and soft tissue infections (SSSI) including osteomyelitis. While they were also seen as useful in respiratory tract infections (RTI) this was not the main therapeutic focus of the early fluoroquinolones.
منابع مشابه
Critique of Research Book (Art)/ A Book for All Seasons: An Analysis of On Photography, by Mohammad Khodadadi Motarjem Zadeh
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